Friedemann Honecker Selected Research

aaptamine

1/2014	Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.
1/2014	Aaptamines from the marine sponge Aaptos sp. display anticancer activities in human cancer cell lines and modulate AP-1-, NF-κB-, and p53-dependent transcriptional activity in mouse JB6 Cl41 cells.
4/2012	Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.

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Friedemann Honecker Research Topics

Disease

34	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 10/2022 - 10/2003
31	Neoplasms (Cancer) 10/2022 - 05/2003
8	Seminoma 08/2021 - 05/2003
5	Neoplasm Metastasis (Metastasis) 01/2020 - 01/2010
5	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 05/2016
4	Embryonal Carcinoma 01/2019 - 05/2003
3	Disease Progression 10/2021 - 10/2003
3	Carcinoma in Situ 10/2004 - 05/2003
2	Testicular Neoplasms (Testicular Cancer) 03/2019 - 07/2014
2	Carcinoma (Carcinomatosis) 01/2017 - 07/2015
2	Necrosis 09/2015 - 06/2012
2	Germinoma 01/2013 - 05/2003
2	Microsatellite Instability 03/2011 - 05/2009
2	Gonadoblastoma 10/2004 - 05/2003
2	Dysgerminoma 10/2004 - 05/2003
1	Circulating Neoplastic Cells 01/2021
1	Testicular Germ Cell Tumor 10/2020
1	Inflammation (Inflammations) 01/2018
1	Breast Neoplasms (Breast Cancer) 01/2018
1	Burkitt Lymphoma (Burkitt's Lymphoma) 12/2017
1	Fibrosis (Cirrhosis) 02/2016
1	Lung Injury 02/2016
1	Dementia (Dementias) 01/2016
1	Thrombosis (Thrombus) 09/2015
1	Urogenital Neoplasms 07/2015
1	Lymphatic Metastasis 01/2013

Drug/Important Bio-Agent (IBA)

23	Cisplatin (Platino)FDA LinkGeneric 10/2022 - 10/2003
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 05/2003
6	ProteomeIBA 06/2017 - 09/2008
4	Pharmaceutical PreparationsIBA 01/2019 - 06/2012
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2018
3	frondoside AIBA 12/2017 - 05/2016
3	Keratins (Keratin)IBA 06/2017 - 07/2014
3	PlatinumIBA 01/2017 - 01/2013
3	AlkaloidsIBA 07/2016 - 04/2012
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2015 - 03/2009
3	aaptamineIBA 01/2014 - 04/2012
2	Messenger RNA (mRNA)IBA 08/2021 - 09/2008
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 08/2021 - 01/2014
2	MicroRNAs (MicroRNA)IBA 01/2021 - 05/2011
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2021 - 01/2013
2	Histone Deacetylase InhibitorsIBA 10/2020 - 11/2016
2	Everolimus FDA Link 03/2019 - 01/2015
2	rhizochalininIBA 06/2017 - 10/2016
2	SphingolipidsIBA 06/2017 - 10/2016
2	Gemcitabine FDA Link 01/2017 - 10/2011
2	TriterpenesIBA 01/2017 - 05/2016
2	GlycosidesIBA 01/2017 - 05/2016
2	Tumor Biomarkers (Tumor Markers)IBA 07/2014 - 01/2010
2	AntibodiesIBA 07/2014 - 03/2009
2	isoaaptamineIBA 01/2014 - 01/2014
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 10/2011 - 01/2003
1	6-methyladenineIBA 08/2021
1	MethyltransferasesIBA 08/2021
1	RNA (Ribonucleic Acid)IBA 08/2021
1	N-methyladenosineIBA 08/2021
1	Fetal Proteins (Fetoprotein)IBA 01/2021
1	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 01/2021
1	Cell-Free Nucleic AcidsIBA 01/2021
1	belinostatIBA 10/2020
1	PanobinostatIBA 10/2020
1	Biological ProductsIBA 01/2020
1	SurvivinIBA 01/2020
1	Small Interfering RNA (siRNA)IBA 01/2019
1	ParaffinIBA 01/2019
1	IsotopesIBA 01/2019
1	Formaldehyde (Formol)FDA Link 01/2019
1	Amino Acids FDA Link 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 12/2018
1	CaspasesIBA 12/2017
1	Protein Isoforms (Isoforms)IBA 06/2017
1	glucose-regulated proteinsIBA 06/2017
1	StathminIBA 06/2017
1	Cytostatic AgentsIBA 01/2017
1	romidepsin (FK228)FDA Link 11/2016
1	abirateroneIBA 10/2016
1	enzalutamideIBA 10/2016
1	Guanidine (Guanidine Nitrate)FDA Link 07/2016
1	Cathepsin BIBA 05/2016
1	Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA 02/2016
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 02/2016
1	nintedanibIBA 02/2016
1	Bleomycin (Blenoxane)FDA LinkGeneric 02/2016
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2016
1	monanchocidinIBA 01/2016
1	Thromboplastin (Tissue Factor)IBA 09/2015
1	Thomsen-Friedenreich antigenIBA 09/2015
1	Hormones (Hormone)IBA 07/2015
1	Epithelial Cell Adhesion MoleculeIBA 07/2014
1	demethyloxyaaptamineIBA 01/2014
1	RetinoidsIBA 01/2014
1	5-hydroxymethylcytosineIBA 01/2013
1	DNA Glycosylases (DNA Glycosylase)IBA 01/2013

Therapy/Procedure

19	Drug Therapy (Chemotherapy) 10/2021 - 01/2003
9	Therapeutics 08/2021 - 10/2003
5	Castration 03/2018 - 07/2015
2	Salvage Therapy 05/2015 - 07/2014
1	Combination Drug Therapy (Combination Chemotherapy) 12/2018
1	Palliative Care (Palliative Therapy) 12/2018
1	Activities of Daily Living (ADL) 01/2016